Why don’t psychedelics work on some people?

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I’ve always been very sensitive too mushrooms, but my girlfriend has never experienced anything from mushrooms. She’s taken upwards of 3 grams and didn’t experience ANYTHING on multiple occasions with mushrooms from various sources.

Every time she took them; she didn’t experience anything. At the same time I’ve taken some from the same batch and had crazy trips at even lower doses than her.

What’s the mechanism at play here?

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